Relevant data from studies meeting inclusion and exclusion criteria were extracted and analyzed.
Search terms were constructed on the basis of the “participants”, “intervention”, “control”, “outcome” and “study type” (PICOS) strategy to systematically search the popular electronic databases. Methods: Randomized and non-randomized controlled studies evaluating relative efficacy of ergocalciferol and cholecalciferol were systematically reviewed to synthesize quantitative and qualitative evidence as per the recommendations of according to “Preferred Reporting Items for Systematic reviews and Meta-analysis” guidelines. The current study aimed to evaluate the relative efficacy of ergocalciferol (vitamin D 2) and cholecalciferol (vitamin D 3) for raising the serum levels of vitamin D metabolites and functional indicators including serum parathyroid (PTH) levels, isometric muscle strength, hand grip strength and bone mineral density. Commonly used interventions to address this deficiency include supplementation and/or fortification with either ergocalciferol (vitamin D 2) or cholecalciferol (vitamin D 3), but the relative efficacy of these two vitamers is unclear.
Background: Widespread prevalence of vitamin D deficiency has been documented globally.
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